![]() ![]() The onset of symptoms among cases was within 30 minutes (8 cases), 30 to less than 120 minutes (8 cases), 2 to less than 4 hours (10 cases), 4 to 8 hours (2 cases), the next day (1 case), and not documented (4 cases).Īnaphylaxis after vaccination is rare in all age groups. Vaccine-specific rates included 1.35 (95% CI, 0.65-2.47) per million doses for inactivated trivalent influenza vaccine (10 cases, 7,434,628 doses given alone) and 1.83 (95% CI, 0.22-6.63) per million doses for inactivated monovalent influenza vaccine (2 cases, 1,090,279 doses given alone). The incidence did not vary significantly by age, and there was a nonsignificant female predominance. The rate of anaphylaxis was 1.31 (95% CI, 0.90-1.84) per million vaccine doses. ![]() We identified 33 confirmed vaccine-triggered anaphylaxis cases that occurred after 25,173,965 vaccine doses. We calculated the incidence of anaphylaxis after all vaccines combined and for selected individual vaccines. Confirmed cases met the Brighton Collaboration definition for anaphylaxis and had to be determined to be vaccine triggered. Medical records of potential cases were reviewed. We first identified all patients with a vaccination record from January 2009 through December 2011 and used diagnostic and procedure codes to identify potential anaphylaxis cases. Using health care data from the Vaccine Safety Datalink, we determined rates of anaphylaxis after vaccination in children and adults. We sought to estimate the incidence of anaphylaxis after vaccines and describe the demographic and clinical characteristics of confirmed cases of anaphylaxis. The risk of anaphylaxis after vaccination has not been well described in adults or with newer vaccines in children. 11 Kaiser Permanente Center for Health Research, and the Rollins School of Public Health, Emory University, Atlanta, Ga.Īnaphylaxis is a potentially life-threatening allergic reaction.10 HealthPartners Institute for Education and Research, Minneapolis, Minn.9 Marshfield Clinic Research Foundation, Marshfield, Wis.8 Center for Health Research, Kaiser Permanente Northwest, Portland, Ore.7 Group Health Research Institute, Seattle, Wash.6 Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, Boston, Mass.5 Institute for Health Research, Kaiser Permanente, Denver, Colo.4 Kaiser Permanente Vaccine Study Center, Oakland, Calif.3 Southern California Kaiser Permanente, Pasadena, Calif.Electronic address: 2 Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga. 1 Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga. ![]()
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